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Brain tumors, especially malignant gliomas, are highly lethal diseases. Although we have achieved some successes with a few individual patients in clinical trials of novel therapeutics, little improvement in overall patient survival has been achieved over the past decade. The high mortality of gliomas is due in part to invasion of normal brain and resistance to conventional radiotherapies.

We recently discovered that a small subpopulation of the brain tumor with stem cell-like properties (called stem cell-like glioma cells) is resistant to irradiation. [More....]

	Jeremy N Rich Laboraory
Duke University Medical Center	Departments of Surgery, Medicine (Neurology), Neurobiology, and The Preston Robert Tisch Brain Tumor Center
	Welcome !
	What's New Brain tumors, especially malignant gliomas, are highly lethal diseases. Although we have achieved some successes with a few individual patients in clinical trials of novel therapeutics, little improvement in overall patient survival has been achieved over the past decade. The high mortality of gliomas is due in part to invasion of normal brain and resistance to conventional radiotherapies. We recently discovered that a small subpopulation of the brain tumor with stem cell-like properties (called stem cell-like glioma cells) is resistant to irradiation. [More....]
Our Laboratory Jeremy Rich, MD Research People Photo Gallery Publications Training Protocols Online CSH Protocols Lab Contacts Journals Nature Journals AACR Journals PubMed Duke e-Journals	What's cool Glioma Cancer Stem Cell and brain tumor radio-resistance full story... Glioma Stem Cell promotes angiogenesis full story... Interaction of TGFb and PTEN pathways in brain tumor cell full story... Target SPARC expression in glioma cells suppress tumor survival full story... AAL881 provides therapeutic benefits for brain tumor patients full story... Focal Adhesion Kinase Inhibitor TAE226 suppress glioma growthfull story... Combination of Raf and mTOR inhibitors provides therapeutic benefit for glioma full story .. Who are we We are a team of physicians and biologists who fight brain tumors! We conduct experimental studies in molecular and cellular biology to explore the mechanism of brain tumorigenesis and cancer progression as well as evaluate the efficacy of novel therapies in preclinical and clinical trials. Our research interests are: 1. Glioma stem cell and brain tumor malignancy 2. Signal transduction pathways in brain tumors 3. Small molecule inhibitors and brain cancer treatments
	Copyright (c) 2007, Qing Shi, Jeremy Rich and Duke University

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